Pape Cheikh, on loan from Marseille, is ineligible for Jose Luis Mendilibar’s side, while Joan Jordan and Jesus Manuel Corona are also sidelined with Achilles and muscular problems.
Lucas Ocampos, on the other hand, returns to the squad after missing the 2-2 draw with Celta Vigo in La Liga last time out owing to a suspension.
Marcos Acuna was sent off late against Celta, but he is fit to play in Manchester and has thus been included in the La Liga team’s squad.
There is also a berth for on-loan Manchester United defender Alex Telles; there was some question about his availability for this match, but he is now available to face his parent club.
Jesus Navas, 37, will return to Manchester after playing for Manchester City from 2013 to 2017 before relocating to Seville.
Youssef En-Nesyri, who represented Morocco at the 2022 World Cup, is Sevilla’s best goal scorer this season, with 14 goals in all competitions.
Meanwhile, former Tottenham Hotspur striker Erik Lamela is the squad’s second-highest goalscorer, with six goals this season.
Rafa Mir has five goals in all competitions, but the team’s other attacking players have struggled to contribute much this season, with Oliver Torres with three goals alongside Ocampos.
Meanwhile, despite appearing on 37 occasions, Ivan Rakitic has only scored twice all season.
Head coach Mendilibar has formation decisions to make for this encounter, but he is expected to continue with a 4-3-3 formation.
Following the league match against Celta last Friday, Oliver Torres, Gonzalo Montiel, and Rakitic might all return to the starting lineup.
Sevilla team vs. Manchester United:
Navas, Montiel, Bade, Marcao, Nianzou, Rekik, Acuna, Telles, Gudelj; Fernando, O Torres, Rakitic, Ocampos, P Gomez, Suso; Lamela, Gil, Mir, En-Nesyri; Lamela, Gil, Mir, En-Nesyri