The Red Devils defeated Newcastle 2-0 at Wembley in February to end their trophy drought and extend Newcastle’s, but the focus is now on the top-four race.
After back-to-back victories over Wolves and Nottingham Forest, the Toon can move above Manchester United with a win at St James’ Park.
Meanwhile, Erik ten Hag’s side has yet to win a league game since beating Newcastle at Wembley and has been thrashed 7-0 by Liverpool.
The Red Devils, on the other hand, are unbeaten in their past six Premier League meetings with the Magpies and have defeated them 14 times at Saint James’ Park in the top tier.
Team news for Newcastle vs. Manchester United
The Magpies will be hoping Nick Pope is fit after pulling out of England’s team for the recent international break.
Leading scorer Miguel Almiron is also out with a thigh injury, but he has participated in individual training over the last week.
Anthony Gordon is also expected to be ready after recovering from an ankle injury, and Sven Botman is being evaluated after withdrawing from the Netherlands squad due to illness.
Joelinton has returned from a two-match suspension and could make an immediate impact on Eddie Howe’s team.
Meanwhile, Casemiro will miss the game as he serves the second of a four-game suspension for receiving two red cards this season.
Christian Eriksen is also sidelined, and Marcel Sabitzer is questionable after suffering a knee injury while on international duty.
Marcus Rashford’s inclusion is not confirmed after he received a knock in England’s 3-1 FA Cup triumph over Fulham, forcing him to miss England’s Euro 2024 qualifiers against Italy and Ukraine.